About Us

gene therapy

gene therapy

gene therapy

gene therapy

gene therapy

gene therapy
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about us

Our DNA

“If you’re going to try to embrace new worlds, you must try to embrace new ideas “ Dr. Phlox, 2151
Phlox Therapeutics is a Dutch start-up company based in Naarden, The Netherlands. The name and logo of Phlox resemble the approach that we use to rescue cardiomyopathies.

The company’s name is inspired by the physician in StarTrek who was the Chief Medical Officer in StarTrek: Enterprise. The motto of Enterprise-D reflects the ambition of Phlox Therapeutics: “to boldly go where no one has gone before.”
members

Our Team

The people at Phlox Therapeutics are leading academics and company builders. Together with investors, advisors and other collaborators, we develop promising gene therapies for the benefit of cardiac patients.
profile picture of Prof. Dr. Yigal Pinto, part of Phlox Therapeutics
Prof. dr. Yigal Pinto 
Prof. Dr. Yigal M Pinto, Founder and CMO of Phlox is a key opinion leader in cardiology and has received numerous awards for his work. Yigal is a professor at the University of Amsterdam, where he leads the department of Experimental Cardiology in conjunction with his clinical practice in cardiology focusing on heart failure. He initiated and executed several prospective clinical trials on heart failure management. The research group of Yigal is specialized in the genetics of human heart failure and the role of RNAs and their application. The group of Yigal generated an EU registry to identify the most important risk factors to guide treatment decisions. This has led to changed clinical guidelines on this topic.

In 2004, his scientific work led to the discovery of galectin-3 as a novel biomarker for heart failure which eventually led to galectin-3 being the second biomarker approved by the FDA for heart failure in 2010. This exemplifies his passion to bring basic biologic insights to clinical concepts and applications. In recent years his group has focused on RNA biology and uncovered a number of novel mechanisms in relation to microRNAs and recently circular RNAs.
Yigal currently coordinates national consortia that aim to translate novel insight in RNA biology toward clinical therapies for patients with cardiomyopathies.
Margien Boels
Margien Boels is the Director of Operations and has over 10 years’ experience in life science and has worked both in the scientific field, as well as in multinational corporations. She obtained her PhD at Leiden University Medical Center in the field of diabetic nephropathy with an emphasis on the treatment of vascular damage. Upon finishing her PhD, she continued her career at Eli Lilly, followed by Nutricia, a Danone company, where she held several medical positions with a focus on chronic diseases, resulting in a strong competence of network building and stakeholder management.

Margien also holds the position of Impact Officer at the Dutch Cardiovascular Alliance. She is dedicated to turn valuable research into impactful start-ups by being the linchpin between scientific researchers, entrepreneurs and potential business partners in the cardiovascular field. With her keen eye for identifying commercial interesting opportunities within the wealth of scientific findings, she supports promising initiatives to establish (start-up) ventures and make them “investor-ready”. 

profile picture of Margien Boels, part of Phlox Therapeutics
profile picture of Prof. Dr. Eva de Rooij, part of Phlox Therapeutics
Prof. dr. Eva van Rooij
Prof. dr. Eva Van Rooij, Founder and CSO of Phlox is a key opinion leader in RNA therapeutics. Eva is Professor at the Hubrecht Institute, and Professor at the University Medical Center, Utrecht in the Netherlands. In her current work, she combines high-end sequencing technologies, stem cells, mouse genetics, animal models of heart disease, and molecular biology to identify important pathways for cardiac remodelling and repair and explore ways to enhance the cardiac efficacy of new drugs.

Eva published over 100 studies in top scientific journals, including Science, JCI, Nature Medicine, Circulation, Circulation Research, Nature Communications and Science Translational Medicine. Currently, she is part of several prestigious (inter)national research networks and was awarded a Vici grant from the Dutch Science Foundation (NWO) in 2020.

During her postdoctoral training in Molecular Biology at UT Southwestern Medical Center in the lab of Dr. Eric Olson, she was a lead scientist in the groundbreaking studies that linked microRNAs to cardiovascular disease. Her work subsequently became the foundation of miRagen’s patent estate on the therapeutic applications of microRNAs in human disease. Eva subsequently was miRagen’s Senior Director of Biology, where she oversaw the pre-clinical studies for the company’s microRNA programs.

profile picture of Prof. Dr. Yigal Pinto, part of Phlox Therapeutics
Prof. dr. Yigal Pinto
Prof. Dr. Yigal M Pinto, Founder and CMO of Phlox is a key opinion leader in cardiology and has received numerous awards for his work. Yigal is a professor at the University of Amsterdam, where he leads the department of Experimental Cardiology in conjunction with his clinical practice in cardiology focusing on heart failure. He initiated and executed several prospective clinical trials on heart failure management. The research group of Yigal is specialized in the genetics of human heart failure and the role of RNAs and their application. The group of Yigal generated an EU registry to identify the most important risk factors to guide treatment decisions. This has led to changed clinical guidelines on this topic.

In 2004, his scientific work led to the discovery of galectin-3 as a novel biomarker for heart failure which eventually led to galectin-3 being the second biomarker approved by the FDA for heart failure in 2010. This exemplifies his passion to bring basic biologic insights to clinical concepts and applications. In recent years his group has focused on RNA biology and uncovered a number of novel mechanisms in relation to microRNAs and recently circular RNAs.
Yigal currently coordinates national consortia that aim to translate novel insight in RNA biology toward clinical therapies for patients with cardiomyopathies.

profile picture of Margien Boels, part of Phlox Therapeutics
Margien Boels
Margien Boels is the Director of Operations and has over 10 years’ experience in life science and has worked both in the scientific field, as well as in multinational corporations. She obtained her PhD at Leiden University Medical Center in the field of diabetic nephropathy with an emphasis on the treatment of vascular damage. Upon finishing her PhD, she continued her career at Eli Lilly, followed by Nutricia, a Danone company, where she held several medical positions with a focus on chronic diseases, resulting in a strong competence of network building and stakeholder management.

Margien also holds the position of Impact Officer at the Dutch Cardiovascular Alliance. She is dedicated to turn valuable research into impactful start-ups by being the linchpin between scientific researchers, entrepreneurs and potential business partners in the cardiovascular field. With her keen eye for identifying commercial interesting opportunities within the wealth of scientific findings, she supports promising initiatives to establish (start-up) ventures and make them “investor-ready”. 

profile picture of Prof. Dr. Eva de Rooij, part of Phlox Therapeutics
Prof. Dr. Eva van Rooij
Prof. dr. Eva Van Rooij, Founder and CSO of Phlox is a key opinion leader in RNA therapeutics. Eva is Professor at the Hubrecht Institute, and Professor at the University Medical Center, Utrecht in the Netherlands. In her current work, she combines high-end sequencing technologies, stem cells, mouse genetics, animal models of heart disease, and molecular biology to identify important pathways for cardiac remodelling and repair and explore ways to enhance the cardiac efficacy of new drugs.

Eva published over 100 studies in top scientific journals, including Science, JCI, Nature Medicine, Circulation, Circulation Research, Nature Communications and Science Translational Medicine. Currently, she is part of several prestigious (inter)national research networks and was awarded a Vici grant from the Dutch Science Foundation (NWO) in 2020.

During her postdoctoral training in Molecular Biology at UT Southwestern Medical Center in the lab of Dr. Eric Olson, she was a lead scientist in the groundbreaking studies that linked microRNAs to cardiovascular disease. Her work subsequently became the foundation of miRagen’s patent estate on the therapeutic applications of microRNAs in human disease. Eva subsequently was miRagen’s Senior Director of Biology, where she oversaw the pre-clinical studies for the company’s microRNA programs.

collaborations

Investors

Our investors
F1RST
Investor
logo image of F1RST Biogeneration Ventures
Investor
3
Investor
2
Investor
4
logo image of F1RST Biogeneration Ventures
F1RST
Investor.
Sponsor One
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Sponsor One
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Sponsor One
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office

Our Location

Gooimeer 2-35 
1411 DC Naarden
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